Where's our resident Mark X owner?
Since you have Altis, I will forget the City and the Vios.
You've listed very good cars.
I feel the ES250 is definitely a good car, but ultimately it is the same K platform that the Camry uses, which makes it a luxury-fied Camry. I'm not sure if its more expensive than a Camry, but between this 2, I will lean towards the Camry Hybrid 2.5L because its a very nice car having sat in it, super spacious, and relatively speaking its spare parts would probably be cheaper than the Lexus parts.
Toyota has proven hybrids, so I wouldn't worry about its battery or anything like that. Plus it has an 8 year warranty.
My advice? Bring the wife to view ES250 and Camry Hybrid and see which is nicer to sit, drive, and the general feeling. If you're in this class of cars, forget about the others.
Alternatively, the X70, CX-5 are good choices in the same price segment. Again, I would sooner choose the X70 over the City/Vios, as there's more space, and better refinement.