Dyno is a great tool to tune a car in a controlled and safe environment. It is good for full load and constant speed load tune. Dyno is a best used to tune ignition timing as well.
From my observation most famous tuners will start on a dyno and eventually going on-road or the tracks to fine tune throttle responds, quick gear up and down shifts plus other factors which dyno can't mimic. To me, it all depends on the car owner on what he/she wants out from the tune. Some like to save more fuel while others want the most hp and torque.
Conclusion:
Use both methods of tuning to gain the best overall tune for your application.
From my observation most famous tuners will start on a dyno and eventually going on-road or the tracks to fine tune throttle responds, quick gear up and down shifts plus other factors which dyno can't mimic. To me, it all depends on the car owner on what he/she wants out from the tune. Some like to save more fuel while others want the most hp and torque.
Conclusion:
Use both methods of tuning to gain the best overall tune for your application.