generally, since i don't see your wiring connection for myself, it's safe to do so. In car electrical system, all sort of grounding will eventually connect to batt -ve, mostly through car chassis. If i were u, i will try the following:
1. Since u oledi found that the sound disappeared when RCA at HU are removed, then it's high chances that the HU grounding could b the culprit. Use multimeter to chk the Pre-out and HU chassis against car chassis.
2. if no multimeter, get a long insulated wires, connect it frm batt -ve to HU metal chassis (for troubleshooting, so juz run the wire directly frm batt to HU through bonnet n front door). Then see if any more sound?
3. if u hv portable player, such as discman, connect 1-to-2 stereo-RCA cable frm discman to amp, to isolate if it's amp/RCA cables/HU/Batt pblm.
4. Very important, make sure no power supply cable running along with the RCA. Becoz RCA carry low level signal that can b easily interfered by power supply line.
5. Sometimes, if RCA are in contact with any part that's vibrating, it will pick up noise.
6. You may also try parallel a 2200uF capacitor across HU +ve and -ve power supply. This will help draining off the +ve power supply high freq noise, if it exists, to ground(this refers to -ve of power supply). But make sure u get at least 16V rating capacitor, because your HU is running at 12~14V from batt.
Hope the above helps to solve ur pblm b4 CNY :)