if you don't know the basics of tuning, better leave it to the specialist.. you probably won't blow your engine with VAFC if you tinker with it a bit.. +/- a few points (maybe shorter life for engine due to overheating/random detonation/engine bogs/plug fouling due to too wrong setting), but you probably will get higher FC and lose power on part throttle/full throttle unless you tune it properly..
As for the settings of the VAFC.
The high and low is for setting the fuelling on high cam (VTEC on) and low cam (VTEC off). I haven't touched a VAFC in a while, but last I remember, it has 24 points for each setting.. 24 for low, 24 for high. I could be wrong though.. it's been a while, and I possible could have mixed up with other Apexi stuff like the SAFC or PowerFC.
In simple english.
If you want to tune VAFC..
A) you need a dyno/something that can measure power increase/fuel ratio/time (butt dyno j/k, RSM, A/F meter, etc.)
B) you need to understand what is 'stoich' and how flow increases with RPM (it's not linear), and thus make decisions on how much time you want the injector to open at xxxxRPM.
C) you need to know how the engine works, and what is the reasonable amount of power you can generate from the engine without making it a one hit wonder (i.e. fast for a while.. until the engine kantoi)